Other CNS depressants to avoid include other opioids, benzodiazepines, and sleep aids. There was no pharmacokinetic interaction between. It is a central nervous system (CNS) depressant, and taking codeine in conjunction with other CNS depressants can cause profound drowsiness and slow breathing to perilously low levels.Īlcohol is a CNS depressant and is also hard on the liver, so it should also be avoided when taking Tylenol 3 to prevent harmful side effects. The mean (sem) time-corrected AUC on rest and activity, respectively, were: combination group 22.3 (3.2) and 28.4 (3.4) acetaminophen group 33.0 (3.1) and 40.4 (3.3) and ibuprofen group 34.8 (3.2) and 40.2 (3.4) P<0.01 for each of the four comparisons of combination vs constituent drug.
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Individuals with respiratory ailments, such as COPD or asthma, should be cautious when taking Tylenol 3.Ĭodeine can interact with other substances and lead to unpredictable side effects. COMMON BRAND NAME(S): Cocet, Cocet Plus, Tylenol with Codeine No.3. Examine the active ingredients on medications before taking them to ensure you aren’t taking too much of any one substance, such as acetaminophen, at one time.Ĭodeine has been known to cause some people to experience respiratory issues in the first few days of use. Get information on Acetaminophen Codeine tablets including uses, dosage details. Elimination of acetaminophen is principally by liver metabolism (conjugation) and subsequent renal excretion of metabolites.
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The plasma half-life is 1.25 to 3 hours, but may be increased by liver damage and following overdosage. Both overdose and organ damage can occur rapidly.īecause of this, Tylenol 3 and other medications that contain acetaminophen generally only have up to 325 mg per dose. Acetaminophen is rapidly absorbed from the gastrointestinal tract and is distributed throughout most body tissues.
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It is used to treat mild to moderate pain. Consuming more than the recommended maximum of 4,000 mg per day can lead to permanent damage to the liver, which can ultimately lead to premature death. ACETAMINOPHEN CODEINE (a set a MEE noe fen KOE deen) is a pain reliever. The safety range of acetaminophen is narrow.